Performance of Daily Disposable Contact Lenses in Symptomatic Wearers

Main Article Content

Joachim Nick
Stefan Schwarz
Satu Jarvinen
Ian Chalmers
Carolina Kunnen

Abstract

Purpose
To evaluate the performance of delefilcon A water gradient and narafilcon A silicone hydrogel daily dispos-able contact lenses (CLs) in symptomatic soft CL wearers.


Methods
This multicenter, open-label, crossover study randomized 121 soft CL wearers with symptoms of CL dis-comfort to delefilcon A or narafilcon A for 2 weeks, followed by the alternate lens for 2 weeks. Subjects rated end-of-day (EOD) comfort, EOD dryness, and quality of vision, and investigators rated fit, surface deposits, and surface wettability.


Results
After 2 weeks, all subjective measures were better for delefilcon A than for narafilcon A, including EOD comfort (8.3 ± 1.9 vs. 6.6 ± 2.2), EOD dryness (8.0 ± 2.2 vs. 5.8 ± 2.6), and quality of vision (8.9 ± 1.4 vs. 7.9 ± 1.7), all p<.0001. Average daily wear time (DWT; 13.0 ± 2.8 vs. 12.3 ± 2.6 hr) and average comfort-able DWT (11.6 ± 3.9 vs. 9.3 ± 3.8 hr) were longer for delefilcon A lenses (p<.0001). The proportions of right and left lenses without front surface deposits were twofold higher for delefilcon A than for narafilcon A, and surface wettability was significantly higher for delefilcon A than for narafilcon A p<.0001).


Conclusion
In this population of symptomatic CL wearers, delefilcon A lenses showed superior subjective ratings for comfort, dryness, quality of vision, DWT, and comfortable DWT and better investigator-rated lens sur-face attributes including fewer surface deposits and superior wettability than did narafilcon A lenses after 2 weeks of wear.

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How to Cite
1.
Nick J, Schwarz S, Jarvinen S, Chalmers I, Kunnen C. Performance of Daily Disposable Contact Lenses in Symptomatic Wearers. JCLRS [Internet]. 2020Feb.5 [cited 2020Jul.13];4(1):e1-e11. Available from: http://jclrs.org/index.php/JCLRS/article/view/35
Section
Original Article

References

1. Morgan PB, Woods CA, Tranoudis IG, et al. Interna-tional contact lens prescribing in 2017. Contact Lens Spectrum 2018;33(1):28–33.
2. Efron N, Nichols JJ, Woods CA, Morgan PB. Trends in US contact lens prescribing 2002 to 2014. Optom Vis Sci 2015;92(7):758–67.
3. Cho P, Boost MV. Daily disposable lenses: the better alternative. Cont Lens Anterior Eye 2013;36(1):4–12.
4. Ichijima H1, Karino S, Sakata H, Cavanagh HD. Improve-ment of subjective symptoms and eye complications when changing from 2-week frequent replacement to daily disposable contact lenses in a subscriber mem-
bership system. Eye Contact Lens 2016;42(3):190–5 5. Fahmy M, Long B, Giles T, Wang CH. Comfort-enhanced
daily disposable contact lens reduces symptoms among weekly/monthly wear patients. Eye Contact Lens 2010;36(4):215–9.
6. Jones L, Brennan NA, Gonzalez-Meijome J, et al; members of the TFOS International Workshop on Contact Lens Discomfort. The TFOS International Workshop on Contact Lens Discomfort: report of the contact lens materials, design, and care subcommittee. Invest Ophthalmol Vis Sci 2013;54(11):TFOS37–70.
7. Keir N, Jones L. Wettability and silicone hydrogel lenses: a review. Eye Contact Lens 2013;39(1):100–8.
8. Stapleton F, Tan J. Impact of contact lens material, design, and fitting on discomfort. Eye Contact Lens
2017;43(1):32–9.
9. Dumbleton K, Woods CA, Jones LW, Fonn D. The
impact of contemporary contact lenses on contact lens discontinuation. Eye Contact Lens 2013;39(1):93–9.
10. Dumbleton K, Caffery B, Dogru M, et al; members of the TFOS International Workshop on Contact Lens Discomfort. The TFOS International Workshop on Contact Lens Discomfort: report of the subcom-mittee on epidemiology. Invest Ophthalmol Vis Sci 2013;54(11):TFOS20–36.
11. DAILIES TOTAL1 [package insert]. Fort Worth, TX: Alcon Laboratories, Inc; 2016.
12. Szczesna-Iskander DH. Comparison of tear film surface quality measured in vivo on water gradient silicone hydrogel and hydrogel contact lenses. Eye Contact Lens. 2014;40(1):23–27.
13. Michaud L, Forcier P. Comparing two different daily disposable lenses for improving discomfort related to contact lens wear. Cont Lens Anterior Eye 2016;39(3):203–9.
14. Insua Pereira F, Lira M. Comfort, ocular dryness, and equilibrium water content changes of daily disposable contact lenses. Eye Contact Lens 2018;44 Suppl 2:S233–40.
15. Marx S, Lauenborg B, Kern JR. Performance evalu-ation of delefilcon A water gradient daily disposable contact lenses in first-time contact lens wearers. Cont Lens Anterior Eye 2018;41(4):335–41.
16. Varikooty J, Schulze MM, Dumbleton K, et al. Clinical performance of three silicone hydrogel daily disposable lenses. Optom Vis Sci 2015;92(3):301–11.
17. Varikooty J, Keir N, Richter D, et al. Comfort response of three silicone hydrogel daily disposable contact lenses. Optom Vis Sci 2013;90(9):945–53.
18. Sterner O, Aeschlimann R, Zürcher S, et al. Friction measurements on contact lenses in a physiologically relevant environment: effect of testing conditions on friction. Invest Ophthalmol Vis Sci 2016;57(13):5383–92.
19. Vidal-Rohr M, Wolffsohn JS, Davies LN, Cerviño A. Effect of contact lens surface properties on comfort, tear stability and ocular physiology. Cont Lens Anterior Eye 2018;41(1):117–21.
20. Lau C, Tosatti S, Mundorf M, et al. Comparison of the lubricity and surface roughness of 5 cosmetic contact lenses. Eye Contact Lens 2018;44 Suppl 2: S256–65.
21. Maissa C, Nelson J, DeCenzo-Verbeten T, et al. Evalu-ation of the lubricity of Dailies Total1 contact lenses after wear. Optom Vis Sci 2014;91(8):e-abstract 145195.
22. Campbell R, Kame G, Leach N, et al. Clinical benefits of a new multipurpose disinfecting solution in silicone hydrogel and soft contact lens users. Eye Contact Lens 2012;38(2):93–101.
23. Young G, Keir N, Hunt C, Woods CA. Clinical evalu-ation of long-term users of two contact lens care pre-servative systems. Eye Contact Lens 2009;35(2):50–8.
24. Lievens CW, Kannarr S, Zoota L, Lemp J. Lid papillae improvement with hydrogen peroxide lens care solution use. Optom Vis Sci 2016;93(8):933–42.
25. Likert R. A technique for the measurement of attitudes. Arch Psychology 1932;140:1–55.